{"id":4,"date":"2016-03-15T09:01:57","date_gmt":"2016-03-15T09:01:57","guid":{"rendered":"http:\/\/color3trial.score012.score-advertising.com\/?page_id=4"},"modified":"2025-04-10T12:28:01","modified_gmt":"2025-04-10T12:28:01","slug":"home","status":"publish","type":"page","link":"https:\/\/color3trial.nl\/","title":{"rendered":"Color 3 Trial"},"content":{"rendered":"\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-4383d167 wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-group alignwide is-layout-flow wp-container-core-group-is-layout-f8561097 wp-block-group-is-layout-flow\" style=\"padding-top:0;padding-right:0;padding-bottom:0;padding-left:0\">\n<div class=\"wp-block-themepunch-revslider revslider\" data-modal=\"false\" data-slidertitle=\"slider1\" style=\"\">\n\t\t\t<!-- START slider1 REVOLUTION SLIDER 6.5.11 --><p class=\"rs-p-wp-fix\"><\/p>\n\t\t\t<rs-module-wrap id=\"rev_slider_1_1_wrapper\" data-source=\"gallery\" style=\"visibility:hidden;background:transparent;padding:0;margin:0px auto;margin-top:0;margin-bottom:0;\">\n\t\t\t\t<rs-module id=\"rev_slider_1_1\" style=\"\" data-version=\"6.5.11\">\n\t\t\t\t\t<rs-slides>\n\t\t\t\t\t\t<rs-slide style=\"position: absolute;\" data-key=\"rs-7\" data-title=\"Slide\" data-duration=\"4010\" data-in=\"o:0;\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"\/\/www.color3trial.nl\/wp-content\/plugins\/revslider\/public\/assets\/assets\/dummy.png\" title=\"Earth View From Space To Europe\" width=\"1200\" height=\"675\" class=\"rev-slidebg tp-rs-img rs-lazyload\" data-lazyload=\"\/\/www.color3trial.nl\/wp-content\/uploads\/2016\/06\/iStock_86970811_XXXLARGE-e1556882092425.jpg\" data-no-retina>\n<!--\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-7-layer-2\" 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title=\"medium-shot-love-story-senior-couple\" width=\"2560\" height=\"1707\" class=\"rev-slidebg tp-rs-img rs-lazyload\" data-lazyload=\"\/\/www.color3trial.nl\/wp-content\/uploads\/2025\/04\/medium-shot-love-story-senior-couple-scaled.jpg\" data-bg=\"p:0% 20%;\" data-no-retina>\n<!--\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-1-slide-5-layer-6\" \n\t\t\t\t\t\t\t\tclass=\"Restaurant-Display\"\n\t\t\t\t\t\t\t\tdata-type=\"text\"\n\t\t\t\t\t\t\t\tdata-color=\"#ffffff\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"x:40px;y:378px;\"\n\t\t\t\t\t\t\t\tdata-text=\"w:normal;s:60;l:60;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:389px;h:68px;\"\n\t\t\t\t\t\t\t\tdata-frame_0=\"x:-50px;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"e:power2.inOut;st:1320;sp:260;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;e:nothing;st:w;sp:100;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:6;font-family:'Raleway';\"\n\t\t\t\t\t\t\t>Quality of Life \n\t\t\t\t\t\t\t<\/rs-layer><!--\n-->\t\t\t\t\t\t<\/rs-slide>\n\t\t\t\t\t<\/rs-slides>\n\t\t\t\t<\/rs-module>\n\t\t\t\t<script type=\"text\/javascript\">\n\t\t\t\t\tsetREVStartSize({c: 'rev_slider_1_1',rl:[1240,1024,778,480],el:[500],gw:[1200],gh:[500],type:'standard',justify:'',layout:'fullwidth',mh:\"400px\"});if (window.RS_MODULES!==undefined && window.RS_MODULES.modules!==undefined && window.RS_MODULES.modules[\"revslider11\"]!==undefined) {window.RS_MODULES.modules[\"revslider11\"].once = false;window.revapi1 = undefined;if (window.RS_MODULES.checkMinimal!==undefined) window.RS_MODULES.checkMinimal()}\n\t\t\t\t<\/script>\n\t\t\t<\/rs-module-wrap>\n\t\t\t<!-- END REVOLUTION SLIDER -->\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\" style=\"padding-top:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50)\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\" style=\"padding-top:var(--wp--preset--spacing--20);padding-right:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--20);padding-left:var(--wp--preset--spacing--20)\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h1 class=\"wp-block-heading has-text-align-left has-accent-3-color has-text-color has-link-color wp-elements-4062ec55681566fe51a4dc01543ede6b\"><strong>COLOR III Trial<\/strong> <\/h1>\n\n\n\n<h1 class=\"wp-block-heading has-text-align-left has-accent-3-color has-text-color has-link-color has-x-large-font-size wp-elements-e5db20c2bf76edb3be6fac13c0aca0b1\">A randomized clinical trial comparing transanal and traditional laparoscopic TME for rectal cancer.<\/h1>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-65eef5bf wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p class=\"has-accent-1-color has-text-color has-link-color has-large-font-size wp-elements-484b1b7e52ab971685d0eafcb521b609\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-accent-3-color\">To improve oncological and functional outcomes of patients with rectal cancer new techniques are being developed. Traditional abdominal laparoscopic resection of low rectal cancer remains challenging with a relative high risk of irradicality.<\/mark><\/strong><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>The introduction of transanal single port surgery has led to the transanal total mesorectal excision (TaTME) technique. The rectum including the total mesorectum is mobilized transanally in a reversed way with minimally invasive surgery. The TaTME technique for low and mid rectal cancer has potential benefits: better specimen quality with better radicality, less morbidity as result of avoiding extraction wounds in the majority of patients and more sphincter saving rectal resections without compromising oncological outcomes.<\/p>\n\n\n\n<p>Currently, cohort series have demonstrated potential benefits of the TaTME for rectal cancer including a low morbidity rate and a high rate of sphincter saving procedures. The COLOR and COLOR II study group have conducted multicenter and international<br>trials including over 2000 patients and demonstrated the benefit of laparoscopic colonic and rectal cancer surgery.<\/p>\n\n\n\n<p>Our goal is to evaluate the TaTME technique compared to conventional laparoscopic rectal resection for patients with mid and low rectal cancer in an international randomized trial: the COLOR III trial. We aim to conduct a high quality trial, with high standards of imaging, surgery, pathology and follow-up with frequent auditing.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"274\" src=\"https:\/\/www.color3trial.nl\/wp-content\/uploads\/2016\/03\/color3-300x274.png\" alt=\"\" class=\"wp-image-46\" style=\"width:295px;height:auto\"\/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:70px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-a4ccfc99 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-background is-layout-flow wp-container-core-column-is-layout-9c23f7b0 wp-block-column-is-layout-flow\" style=\"border-radius:15px;background-color:#ffffff;padding-top:var(--wp--preset--spacing--60);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--40)\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"235\" height=\"156\" src=\"https:\/\/www.color3trial.nl\/wp-content\/uploads\/2016\/03\/stock-photo-73036945-surgery-and-emergency-concept.jpg\" alt=\"\" class=\"wp-image-11\" style=\"width:217px;height:auto\"\/><\/figure>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center has-large-font-size\">Protocol<\/h2>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center has-accent-1-color has-text-color has-link-color has-small-font-size wp-elements-168a64301d6158e52287b76a648bfc21\"><strong>A Multicentre Randomized <br>Clinical&nbsp;Trial&nbsp;comparing&nbsp;transanel TME <br>Versus Traditional Laparoscopic TME for <br>MID and&nbsp;LOW&nbsp;rectal cancer<\/strong><\/p>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons has-custom-font-size has-small-font-size is-vertical is-content-justification-center is-nowrap is-layout-flex wp-container-core-buttons-is-layout-0148032c wp-block-buttons-is-layout-flex\" style=\"border-style:none;border-width:0px;border-radius:15px\">\n<div class=\"wp-block-button has-custom-font-size has-ysabeau-office-font-family has-small-font-size\" style=\"text-transform:uppercase\"><a class=\"wp-block-button__link has-text-color has-link-color wp-element-button\" href=\"\/?page_id=23#flowchart\" style=\"border-radius:10px;color:#ffffff\">Flowchart<\/a><\/div>\n\n\n\n<div class=\"wp-block-button has-custom-font-size has-ysabeau-office-font-family has-small-font-size\" style=\"text-transform:uppercase\"><a class=\"wp-block-button__link has-text-color has-link-color wp-element-button\" href=\"\/?page_id=23#startdate\" style=\"border-radius:10px;color:#ffffff\">Start day trial<\/a><\/div>\n\n\n\n<div class=\"wp-block-button has-custom-font-size has-ysabeau-office-font-family has-small-font-size\" style=\"text-transform:uppercase\"><a class=\"wp-block-button__link has-text-color has-link-color wp-element-button\" href=\"\/?page_id=23#synopsis\" style=\"border-radius:10px;color:#ffffff\">Synopsis trial<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-background is-layout-flow wp-container-core-column-is-layout-9c23f7b0 wp-block-column-is-layout-flow\" style=\"border-radius:15px;background-color:#ffffff;padding-top:var(--wp--preset--spacing--60);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--40)\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"235\" height=\"156\" src=\"https:\/\/www.color3trial.nl\/wp-content\/uploads\/2016\/03\/stock-photo-68714279-the-operation-was-a-complete-success.jpg\" alt=\"\" class=\"wp-image-10\" style=\"width:217px;height:auto\"\/><\/figure>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center has-large-font-size\">Participation<\/h2>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center has-accent-1-color has-text-color has-link-color has-small-font-size wp-elements-153200eae4cb4bb7d6f8bdaa32e2edca\"><strong><strong>To assure technical and oncological quality of the TaTME technique, all participating centers will be conducted a surgical quality assessment.<\/strong><\/strong><\/p>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons has-custom-font-size has-small-font-size is-vertical is-content-justification-center is-nowrap is-layout-flex wp-container-core-buttons-is-layout-0148032c wp-block-buttons-is-layout-flex\" style=\"border-style:none;border-width:0px;border-radius:15px\">\n<div class=\"wp-block-button has-custom-font-size has-ysabeau-office-font-family has-small-font-size\" style=\"text-transform:uppercase\"><a class=\"wp-block-button__link has-text-color has-link-color wp-element-button\" href=\"\/?page_id=25#investigators\" style=\"border-radius:10px;color:#ffffff\">Main Investigators<\/a><\/div>\n\n\n\n<div class=\"wp-block-button has-custom-font-size has-ysabeau-office-font-family has-small-font-size\" style=\"text-transform:uppercase\"><a class=\"wp-block-button__link has-text-color has-link-color wp-element-button\" href=\"\/?page_id=25#centers\" style=\"border-radius:10px;color:#ffffff\">Participating Centers<\/a><\/div>\n\n\n\n<div class=\"wp-block-button has-custom-font-size has-ysabeau-office-font-family has-small-font-size\" style=\"text-transform:uppercase\"><a class=\"wp-block-button__link has-text-color has-link-color wp-element-button\" href=\"\/?page_id=25#publications\" style=\"border-radius:10px;color:#ffffff\">Publications<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-background is-layout-flow wp-container-core-column-is-layout-9c23f7b0 wp-block-column-is-layout-flow\" style=\"border-radius:15px;background-color:#ffffff;padding-top:var(--wp--preset--spacing--60);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--40)\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"235\" height=\"156\" src=\"https:\/\/www.color3trial.nl\/wp-content\/uploads\/2016\/03\/stock-photo-57649334-surgical-lamps-take-with-blue-filter.jpg\" alt=\"\" class=\"wp-image-9\" style=\"width:217px;height:auto\"\/><\/figure>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center has-large-font-size\">Useful tools<\/h2>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center has-accent-1-color has-text-color has-link-color has-small-font-size wp-elements-85f2c793648c65e50c73337e7dcfdf22\"><strong><strong>Data entry, including report of a SAE,&nbsp; can be done directly into the eCRF\u2019s on the online platform. On the download page you can find pdf\u2019s and most forms and other useful documents.<\/strong><\/strong><\/p>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons has-custom-font-size has-small-font-size is-vertical is-content-justification-center is-nowrap is-layout-flex wp-container-core-buttons-is-layout-0148032c wp-block-buttons-is-layout-flex\" style=\"border-style:none;border-width:0px;border-radius:15px\">\n<div class=\"wp-block-button has-custom-font-size has-ysabeau-office-font-family has-small-font-size\" style=\"text-transform:uppercase\"><a class=\"wp-block-button__link has-text-color has-link-color wp-element-button\" href=\"https:\/\/prod.tenalea.net\/coloriii\/dm\/\" style=\"border-radius:10px;color:#ffffff\">Randomization tool<\/a><\/div>\n\n\n\n<div class=\"wp-block-button has-custom-font-size has-ysabeau-office-font-family has-small-font-size\" style=\"text-transform:uppercase\"><a class=\"wp-block-button__link has-text-color has-link-color wp-element-button\" href=\"https:\/\/prod.tenalea.net\/coloriii\/dm\/\" style=\"border-radius:10px;color:#ffffff\">Data Entry<\/a><\/div>\n\n\n\n<div class=\"wp-block-button has-custom-font-size has-ysabeau-office-font-family has-small-font-size\" style=\"text-transform:uppercase\"><a class=\"wp-block-button__link has-text-color has-link-color wp-element-button\" href=\"\/?page_id=27#downloads\" style=\"border-radius:10px;color:#ffffff\">Downloads &amp; Video\u2019s<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<figure class=\"wp-block-image size-full wp-duotone-182949-f4f3f0-1\" style=\"margin-top:0;margin-right:0;margin-bottom:0;margin-left:0\"><img loading=\"lazy\" decoding=\"async\" width=\"6160\" height=\"1581\" src=\"https:\/\/www.color3trial.nl\/wp-content\/uploads\/2016\/06\/wereldbol.jpg\" alt=\"\" class=\"wp-image-458\" srcset=\"https:\/\/www.color3trial.nl\/wp-content\/uploads\/2016\/06\/wereldbol.jpg 6160w, https:\/\/www.color3trial.nl\/wp-content\/uploads\/2016\/06\/wereldbol-300x77.jpg 300w\" sizes=\"auto, (max-width: 6160px) 100vw, 6160px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>COLOR III Trial A randomized clinical trial comparing transanal and traditional laparoscopic TME for rectal cancer. To improve oncological and functional outcomes of patients with rectal cancer new techniques are being developed. Traditional abdominal laparoscopic resection of low rectal cancer remains challenging with a relative high risk of irradicality. The introduction of transanal single port [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-4","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/color3trial.nl\/index.php?rest_route=\/wp\/v2\/pages\/4","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/color3trial.nl\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/color3trial.nl\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/color3trial.nl\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/color3trial.nl\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4"}],"version-history":[{"count":254,"href":"https:\/\/color3trial.nl\/index.php?rest_route=\/wp\/v2\/pages\/4\/revisions"}],"predecessor-version":[{"id":1196,"href":"https:\/\/color3trial.nl\/index.php?rest_route=\/wp\/v2\/pages\/4\/revisions\/1196"}],"wp:attachment":[{"href":"https:\/\/color3trial.nl\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}